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HMG CoA Reductase Inhibitors

These medications, packaged under the names Mevacor, Pravachol, Zocor, Lipator or Lescol, block the production of cholesterol within cells, causing the cells to increase specific receptors on their surface that will take up LDL cholesterol particles from the blood. This effect is especially prominent in the liver, which is the organ that largely controls cholesterol in the body. As the number of LDL receptors increases, the levels of total and LDL cholesterol in the blood will go down.

Effects on Blood Lipids.

Effects On Blood Lipids
Total cholesterol and LDL cholesterol are reduced 15 to
40 percent
Triglyceride levels may decline 10 to 15 percent
HDL cholesterol levels increase 5 to 10 percent

Taken with other medication, such as cholestyramine resin, has led to reversal of coronary artery blockage in a substantial number of patients.

Adverse Reactions
Temporary elevation of liver enzyme blood test has
occurred in a small percentage of patients
Elevations of liver enzyme blood tests that are significant.
Doctor will discontinue treatment
Stomach discomfort
Muscle pains, unusual cramps or weakness
Skin rash

Drug Interaction
Consult with your CCND physician about taking HMG CoA Reductase Inhibitors if you are taking cyclosporin, gemfibrozil, niacin, erythromycin or any other prescription medication, particularly those prescribed for cholesterol/lipid lowering purposes.

Times and amounts vary by patient; consult your physician or pharmacist. Typically, the drug is taken in the evening with food for better absorption.

Source: Lipid Metabolism and Atherosclerosis Clinic Baylor College of Medicine/The Methodist Hospital 3/94

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The information contained in this web site is presented for information purposes only, and is not intended to substitute in any way a consultation with a physician or competent healthcare professional for medical diagnosis and/or treatment.