HMG CoA Reductase Inhibitors
These medications, packaged under the names Mevacor, Pravachol,
Zocor, Lipator or Lescol, block the production of
cholesterol within cells, causing the cells to increase specific receptors
on their surface that will take up LDL cholesterol particles from the
blood. This effect is especially prominent in the liver, which is the
organ that largely controls cholesterol in the body. As the number of
LDL receptors increases, the levels of total and LDL cholesterol in the
blood will go down.
Effects on Blood Lipids.
Effects On Blood Lipids
Total cholesterol and
LDL cholesterol are reduced 15 to
Triglyceride levels may
decline 10 to 15 percent
HDL cholesterol levels
increase 5 to 10 percent
Taken with other medication, such as cholestyramine resin, has led to
reversal of coronary artery blockage in a substantial number of patients.
Temporary elevation of
liver enzyme blood test has
occurred in a small
percentage of patients
Elevations of liver enzyme
blood tests that are significant.
Doctor will discontinue
Muscle pains, unusual
cramps or weakness
Consult with your CCND physician about taking HMG CoA Reductase Inhibitors
if you are taking cyclosporin, gemfibrozil, niacin, erythromycin or any
other prescription medication, particularly those prescribed for cholesterol/lipid
Times and amounts vary by patient; consult your physician or pharmacist.
Typically, the drug is taken in the evening with food for better absorption.
Source: Lipid Metabolism and Atherosclerosis Clinic Baylor
College of Medicine/The Methodist Hospital 3/94