Fibric Acid Derivatives

Definition
Fibric Acid Derivatives are drugs under the brand names Lopid (gemflbrozil) or Atromid-S (clofibrate) that enhance the body's ability to break down triglyceriderich lipid particles, and, as a result, effectively reduce triglyceride levels.

Uses
In patients with very high triglyceride levels, the reduction of triglycerides by these drugs can decrease the risk of inflammation of the pancreas, a very dangerous condition. In patients at risk for heart disease, these drugs have been shown to reduce the rate of development of heart attacks and coronary deaths.

Effects On Blood Lipids
Triglycerides are reduced 25 to 50 percent
HDL Cholesterol is increased 10 to 20 percent
Total cholesterol and LDL cholesterol are usually reduced
10 to 15 percent

Adverse Reactions
Stomach discomfort and nausea
Skin rash
Abnormal liver enzyme tests
Muscle pains
Diarrhea
Makes the bile thicker and increases risk of gall bladder
problems
Can potentiate the blood-thinning effect of warfarin
(Coumadin)

Dosage
Consult your CCND physician about the appropriate times of day and quantities of this drug. Usually recommended to be taken slightly before or with meals.

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